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Sambandamurthy VK, Wang XJ, Chen B, Russell RG, Derrick S, Collins FM, et al

However, this also means it can contribute to anxiety, chronic pain, sensory overstimulation, muscle tension, sleep disruption, heart palpitations, and neurodegeneration

2.1.7 Adenosine Adenosine is a ubiquitous local modulator that interacts with four membrane receptors: A1, A2A, A2B, and A3 to regulate various physiological and pathological processes (90)

Molecular docking analyses demonstrated that ginsenoside Rb1 can bind to TLR4 (118), while ginsenoside Rf was identified as a potential ligand for peroxisome proliferator-activated receptor gamma (PPAR), a nuclear receptor that plays an important role in regulating inflammation by controlling the expression of COX-2 (119)