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Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter

Nanomedicine targeting mitochondria is the key to solve this problem

This criteria identified methylcobalamin, acetyl-L-carnitine, and vitamin E, though upon review of the literature, randomized trials of vitamin E in high and regular dosing did not meet primary endpoints [104,105,106], and is associated with increased risk of hemorrhage [107] and slight increased risk of prostate cancer [108], and is not recommended by consensus guidelines [98]

This regulatory relationship, termed the metabolic-immune axis, is a crucial factor in the development of immune escape mechanisms by tumors

Cell Mol Life Sci 63:30613071