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Preclinical Research in Musculoskeletal Models A 2024 musculoskeletal healing narrative review summarized decades of preclinical work and acknowledged the breadth of laboratory findings

Interestingly, PD is also associated with iron overload and lipid peroxidation, which are highly consistent with ferroptosis, a form of regulated cell death that is initiated by iron-dependent phospholipid peroxidation (4)

The proteins identified are listed in Table 1

In conclusion, compared to normal cells, tumor cells exhibit a significantly higher ratio of de novo synthesized fatty acids, and this metabolic shift is positively correlated with tumor malignancy (62)

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