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Although not considered a change in structure to the BBB per se, endothelial cells can increase leukocyte adhesion molecule expression leading to increased leukocyte extravasation into the brain parenchyma under pathological conditions [58, 59]

Jagetia GC, Aggarwal BB

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Hence, targeting neutrophil-mediated oxidative stress has emerged as a key strategy for preventing and treating HIRI, with antioxidant therapies gaining increasing attention