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When NRF2 translocates to the nucleus, it binds antioxidant response elements (AREs) in the promoter regions of GST genes, upregulating their expression

Table S7), suggesting independent inversion events within the locus

Upon LYSET deletion, a significant increase of both uncleaved and cleaved GNPT in the lysosome was observed

Additional studies have shown that spinal fusion may result in degeneration of adjacent discs and lead to further discogenic pain, herniation, stenosis or spondylosis, suggesting that improvements in surgical interventions for back pain are necessary (Ghiselli et al., 2004)

HPLC consumables and solvents were from Agilent Technologies (Mississauga, ON, Canada), and Fisher Scientific (Mississauga, ON, Canada), respectively