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In addition, reduced expression of insulin receptors (IRs) in synaptic membranes was accompanied by reduced learning/memory ( Streptozotocin infusion in rodents results in the development of sAD phenotypes, including hyperphosphorylation of tau proteins and loss of synaptic plasticity in the cerebral cortex (Figures 4, 5)

On the follow up duplex Doppler ultrasonography analysis for plaque in Area Two, 32 were non-calcified and 8 were calcified, a 43% decrease in calcified plaque

For both classes, the expansion, specific genomic organization and high sequence similarity among duplicated members have important implications