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A placebo-controlled crossover trial in 35 healthy middle-aged adults found taking a single 25-gram dose of freeze-dried wild blueberry powder improved performance on tests of cognitive function, particularly those involving more demanding mental tasks

L.RiebelingT.NischeR.SchmitzJ.et al (2022b)

The Efficacy of Metformin as a Therapeutic Agent in the Treatment of Acne Vulgaris: A Systematic Review

simultaneously, the inflammatory cascade initiated by the passage of peripheral cytokines into the central nervous system compromises the structural integrity of astrocytes and their ability to reuptake glutamate, as well as leads to damage of oligodendrocytes, the glial cells that produce myelin (Kradttir and Attwell, 2007