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ATP released from cells undergoing ICD after radiotherapy or chemotherapy plays a crucial role in anti-tumor immune stimulating processes, as discussed earlier, while its main metabolite, adenosine plays important roles in immune suppression by inhibiting the activities of APTs including DCs, and triggering apoptosis in NK cells and CTLs [86]

Rosadini G, Marenco S, Nobili F, et al

It is upregulated in response to tissue injury, hypoxia, metabolic stress, and inflammation acting as a damage-sensing and repair-initiating signalling complex

Nat Biotechnol 25(10):1165 Liu J, Yu M, Zhou C, Zheng J (2013) Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology

This could include itchiness, a rash, hives, chest tightness, shortness of breath and swelling of the throat, lips, mouth or tongue