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10.1016/j.jconrel.2013.10.017 13 HavanurS.JagadeeshbabuP

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Clinical trials with a single natural compound on cancer Curcumin In a randomized double-blind placebo-controlled trial, patients with liver cirrhosis were randomly divided into two groups to receive 1000 mg/day curcumin or placebo for 3 months, beneficial effects of curcumin supplementation were observed in downregulating disease activity scores and severity of cirrhosis in patients

Specifically, one RD each from two neighbouring CBS dimers interact in a butterfly-like dimeric arrangement, related by C2 symmetry, such that the loop 516525 from an RD of one dimer forms a clasp around an RD of the neighbouring dimer