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10.1038/s41398-018-0317-1 178 WuX.GuanY.WangJ.SongL.ZhangY.WangY.et al (2024a)

Recent Preclinical and Clinical Progress in Liposomal Doxorubicin

(2019) reported that mitophagy declines in the late stages of diabetic retinopathy (DR) and is decoupled from mitochondrial biogenesis during the progression of the disease

Traditional approaches, including oral and intravenous administration, have offered limited success due to challenges such as poor bioavailability, inability to cross the BBB, and systemic side effects