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We, therefore, speculate that these signaling differences between DA and NE may provide islet cells with an additional mechanism for finer temporal control of hormone release that may be especially critical for differential metabolic adaptations to states of acute and chronic stress when concentrations of circulating catecholamines are altered

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For HT-qPCR analysis, 22 gene sequences were selected

doi: 10.1016/j.tig.2023.11.002 [DOI] [PubMed] [Google Scholar] 66.Wang S, Yang H, Yang Z, et al

We next optimized a NRF2 transcriptional signature resulting in a set of 59 genes based on their contribution to the model and overlap with previously reported NRF2 signatures (Figs