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J Geriatr Psychiatry Neurol 30:50-59, 2017 9

Lai MM, Hong JJ, Ruggiero AM, Burnett PE, Slepnev VI, De Camilli P et al (1999)

In other words, first-pass metabolism describes reduced bioavailability when you consume something orally

Thiazide diuretics, like hydrochlorothiazide, have been associated with intrahepatic cholestatic jaundice (rare)

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