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The 2007 trial included 412 participants

Donath MY, Boni-Schnetzler M, Ellingsgaard H, Ehses JA

Results Structural determination We fused thermostabilized BRIL at the N-terminus of the ghrelin receptor and applied the NanoBiT tethering strategy to improve complex stability and homogeneity (Supplementary Fig

Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated