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Increasing Demand for Personalized Medicine The rise of personalized medicine is driving the development of targeted therapies tailored to individual patient needs and genetic variations

Mechanistically, the beneficial effect of anthocyanins on cardiovascular health include working as an antiplatelet agent in atherosclerosis and other CVD prevention, inducing nitric oxide formation in vessel thereby enhancing vasorelaxation, protecting cardiac cells from oxidative-stress-induced apoptosis, and increasing HDL cholesterol as well (Gaiz et al., 2018

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4 The renoprotection of SIRTs and HDACs activators and inhibitors 4.1 Activators SIRTs are an evolutionarily highly conserved family of deacetylases and dependent on NAD +

Reversible, plastic resistance in prostate, breast, colon, pancreatic, and non-small cell lung cancer cell line models has been shown to be a consequence of nutrient deprivation which introduces ROS and low cell proliferation, priming cells to adapt to anti-tumor agents such as the mitochondrial ETC Complex I inhibitor metformin (Marini et al., 2016