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For instance, a dandelion-derived polysaccharide was shown to inhibit the PI3K/Akt pathway, downregulating HIF-1 and VEGF expression, and thereby suppressing tumor angiogenesis (138)

In some cases, at least two or more types of programmed cell death may occur because of diabetic complications

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Immunofluorescence assay for hypoxia marker (HIF-1) Coronal slices (7 m thick) mounted on a poly-L-Lysine coated glass slides were first immersed in ice-cold acetone for 5 min