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(2016) Effects of two-year Vitamin B12 and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: Additional results from the B-PROOF study, an RCT, Nutrients, Vol 8, No.11 [online] Available at: De La Torre-Iturbe, S., Vazquez-Roque, R.A., De la Cruz-Lopez, F., Flores, G

The rate-limiting step in glutathione synthesis is the availability of cysteine, which can be obtained from the diet or synthesized de novo from methionine