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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

Muscle Satellite Cells and Aging While initially targeted at fat, NNMT inhibitors have shown surprising potential in muscle tissue

Demyelination induces axonal defects, such as nodal complex alterations, conduction blocks, and/or irreversible axon losses that clearly disrupt long-range connectivity (Nave, 2010), as in multiple sclerosis (MS), an autoimmune disease targeting OLGs

Vitamins C and E can help protect the skin from oxidative stress, which can exacerbate eczema symptoms

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