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However, excessive accumulation of GSH precursors can overwhelm this reducing capacity, leading to reductive stress and aberrant mitochondrial H 2 O 2 production, a mechanism that is particularly pronounced in cancer cells characterized by elevated cysteine metabolism but limited antioxidant enzyme capacity 209

In addition, several studies reconfirmed chondrocyte ferroptosis existing in OA and provided some potential therapeutic strategies [23,24,25,26]

Our data also suggests that chelation does not seem a treatment of choice for the elimination of gadolinium

So, the average body weight of American men and women has changed dramatically even just in the past 25 years