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Disclosures: Sudeep Tanwar: Nothing to Disclose, Walter Gregory: Nothing to Disclose, The ELUCIDATE Investigators: Nothing to Disclose, Peter Selby: Nothing to Disclose, William Rosenberg: Nothing to Disclose 2039 SERUM THROMBOSPONDIN 2 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 PREDICT ADVANCED LIVER FIBROSIS IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY Rambabu Surabattula 1 Valentina Strohmeier 2 Anna-Maria Globig 2 Sudha Myneni 1 Maximilian Heeg 2 Gerhard Kindle 2 Sigune Goldacker 2 Caroline von Spee-Mayer 2 Michele Proietti 3 Birke Bausch 2 Dominik Bettinger 2 Michael Schulthei 2 Robert Thimme 2 Klaus Warnatz 2 Detlef Schuppan 1 , 1 University Medical Center Mainz, 2 University Medical Center Freiburg, 3 Hannover Medical School Background: Timely detection of segmental fibrosis and portal hypertension as a manifestation in a significant subgroup of patients with CVID (Common Variable Immunodeficiency) is a challenge, as it is usually not associated with classic liver cirrhosis

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A clinicians view

Most have involved the use of in vitro cultures exposed to blue-light or oxidative stress inducers such as hydrogen peroxide