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However, during a situation where massive apoptosis cannot be completed and converts into secondary necrosis with cell swelling and cell contents release, the extensive caspase activation of the primary apoptosis is still measurable [44]

As a key regulator of inflammatory cell death, ROS have recently been found to affect GSDMDs palmitoylation through various mechanisms

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Allen JW, Mutkus L, Aschner M (2001) Methylmercury-mediated inhibition of 3H-d-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase