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These results are consistent with expectations based on the results for the model system: the better alignment of the orbitals in the 5-membered ring adduct (dihedral angle very close to the optimum 90) results in a more favorable interaction energy than in the 6-membered ring adduct (dihedral angle of 102)

Zapun, A., Bardwell, J

patens , one of the three genes does not seem to be expressed at all (Liu et al., 2013)

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However, the mechanisms of action for certain agents, such as insulin analogs and some SGLT-2 inhibitors, remain incompletely understood, and further clinical studies are needed to verify their long-term efficacy and cardiovascular outcomes