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Metabonomic and transcriptomics analysis showed that branched chain amino acid degradation, glycine synthesis, and glutamine metabolism pathways were significantly dysregulated in fatty liver, interacting with fatty acid metabolism and exacerbating liver lipid accumulation [45,46,47]

In addition, melatonin protects against ferroptosis by reducing the expression of the H2O2-producing LOX enzymes [414, 418] and has the potential to do so by reducing the expression of the H2O2-producing NOX enzymes [419,420,421,422]

RESULTS Reduced protein-SSG is associated with decreased glutathione pools by CHAC1 induction in multiple cell types undergoing ferroptosis To investigate the pattern of protein-SSG in ferroptotic cells, we used the classical and commonly used ferroptosis inducer erastin because it can extensively induce ferroptosis in cells

10.1073/pnas.90.11.5242 223 PriyadarshaniP.LiY.YaoL

(Reference Haghighatdoost and Hariri17) Nevertheless, these claims are still controversial, both in matters of long-term effectiveness and dosages needed to evoke them