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The underlying mechanisms are subject to continued scrutiny and are likely to be complex

The role of NCOA4 in ferroptosis was determined by silencing the expression of NCOA4 by siRNA lentiviral transfection, and the result shows that an iron chelator-like effect was produced in the NCOA4-deficient KGN after ferric citrate (FAC) intervention (Fig

3a), which resemble earlier results from zebrafish 44,45

These antibodies are used to treat a variety of solid and blood tumors and include anti-CTLA-4 antibodies (ipilimumab), anti-PD-1 antibodies (nivolumab, pembrolizumab), and anti-PD-L1 antibodies (atezolizumab, durvalumab, avelumab)