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The only food supplement shown to directly affect the production of NO is GPLC

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Melatonin and the circadian clock in Mink: effects of daily injections of melatonin on circadian rhythm of locomotor activity and autoradiographic localization of melatonin binding sites

Overall, L-arginine might have a positive role in the treatment of PD based on current data, and the authors support its use in combination regimen

As the efficacy of a treatment for PD is evaluated partly using subjective PD and ED questionnaires, we hypothesize that some effects of these drugs might be attributed to a placebo effect as opposed to a real response