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More recently, to target the vasculogenic mimicry (induced by hypoxia and rapidly invading tumor cells) by platelet mimetic pH/redox sensitive nanogels co-loaded with doxorubicin (120 nm size, 16 mV zeta potential) were developed by Li and co-workers

However, beyond masking the allogeneic properties of the sperm cell, the accompanying increase in electronegativity brought about by sialyation has formed the basis of electrophoretic separation techniques designed to rapidly fractionate mature spermatozoa away from other deleterious ejaculate contaminates (i.e., immature germ cells, bacteria, and leucocytes) (90) ( Figure 1 )

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Future studies are needed to further elucidate its direct regulatory effect on novel pyroptotic molecules such as gasdermin E

Gene-editing therapies aim to correct the genetic defects or pathological processes underlying PD at their source, with the goal of directly intervening in the disease's genetic or molecular etiology, protecting neurons, and halting or delaying disease progression [214]