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Patients with darker skin should be cautious of undergoing lasers and harsh chemical peels, as ethnic skin is more prone to hyperpigmentation or post-inflammatory hyperpigmentation (PIH) due to the naturally higher amount of melanin in the skin

Emerging evidence suggests that tryptophan metabolism is closely linked to mitochondrial dysfunction in diseases, with tryptophan metabolites capable of inhibiting mitochondrial damage and alleviating inflammatory injury [120]

The polymerization is unrelated to the catalytic activity, but probably has an important role such as formation of multienzyme complexes

Specifically, adk encodes adenylate kinase, aroE encodes shikimate dehydrogenase required for chorismate biosynthesis, fumC encodes fumarate hydratase of the tricarboxylic acid cycle (TCA), gdh encodes the glucose-6-phosphate 1-dehydrogenase, pdhC ( aceE ) encodes the pyruvate dehydrogenase subunit E1, and pgm encodes phosphoglucomutase

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