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Keywords: H2 antagonists, diabetes, neuropathy, folic acid, magnesium, microbiome Introduction Diabetes has a global impact on health, with 415 million known adult cases, of which 91% have type 2 diabetes (T2DM)

[23], these scores rely mostly on clinical comorbidities, rather than thrombogenic mechanisms such as blood stasis, hypercoagulability and endothelial dysfunctionknown as Virchows triad. In view of the above arguments, it does seem very timely to revisit these, and indeed to develop new methods of assessment based on markers of thrombotic problems including biochemical markers such as those in Table 5, more physiological methods of endothelial dysfunction such as flow-mediated dilatation [378], and, in particular, fibrinaloid microclots