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In addition to increasing height in children and adolescents, growth hormone has many other effects on the body: Increases calcium retention, [41] and strengthens and increases the mineralization of bone Increases muscle mass through sarcomere hypertrophy Promotes lipolysis [42] Increases protein synthesis [43] [44] Stimulates the growth of all internal organs excluding the brain Plays a role in homeostasis Reduces liver uptake of glucose Promotes gluconeogenesis in the liver [45] Contributes to the maintenance and function of pancreatic islets Stimulates the immune system Increases deiodination of T4 to T3 [46] Induces insulin resistance [47] Biochemistry [edit] GH has a short biological half-life of about 10 to 20 minutes