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Metformin and acid-reducing drugs (e.g., omeprazole) can lower B12 absorption over time

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One study conducted high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy on degenerated adult human lumbar discs and demonstrated a correlation between changing metabolite concentrations and degrees of degeneration (Radek et al., 2016)

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the compounds described by Wu, Takahasi, or Rahbar may be used in combination with the formulation described herein