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Of the amphetamine-like stimulants, methylphenidate is often preferred for MS fatigue because of its well-known safety profile and relatively lower cost

At the 3 end of the gene, alternative splicing gives rise to at least three subsets of RNA transcripts, each encoding three distinct carboxy-terminal portions of the unique E-domain extension-peptide (E-peptide) as well as the 3-untranslated region (3UTR) (17,25,3136)

LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition

In refractory cases that have not responded to conservative management or nerve blocks, surgical decompression of the lateral femoral cutaneous nerve may be considered as a last resort

FIGURE 2 Epigenetic modifications in key genes related to stress and immunity, such as nuclear receptor subfamily three group C member 1 (NR3C1), TNF, and nuclear factor kappa B (NF-B), modulate both the negative feedback of the HPA axis and inflammatory pathways mediated by NF-B, suggesting a link between endocrine dysregulation and immune activation (Palma-Gudiel et al., 2021)