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While clinical applications have traditionally focused on high-dose intravenous (IV) administration, lower-dose subcutaneous protocols are increasingly explored in research settings as a more practical and consistent approach

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however, larger, controlled clinical trials are necessary to validate these findings and establish standardized treatment protocols

The administration of ACTH and its analogues in humans has been associated with general CNS activation consisting of a decreased sleep period time and sleep efficiency, and an increase of sleep latency (39, 44)

Early endocrine and metabolic changes after bariatric surgery in grade III morbidly obese patients: a randomized clinical trial comparing sleeve gastrectomy and gastric bypass