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The interaction between hypoxia and mitochondria through the -ketoglutarate-dependent dioxygenase family suggests that interventions targeting this family could potentially prevent hypoxia-induced damage to mitochondria (Figure 1)

A study evaluating patients with Postural Orthostatic Tachycardia Syndrome (POTS) found that a subset of patients were deficient in Vitamin B1, and upon oral supplementation, experienced significant improvement in their dysautonomia symptoms

Most studies sources were searched from Chinese databases consisted of small-sample, single-center studies, leading to publication bias and regional selection bias

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In terms of respective effects: Ipamorelin therapy increases serum GH, appetite, and body weight