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Methodological Confounds That Must Be Considered Before Comparing Cytokine Studies The biological mechanisms of cytokines make a consistent and stable circulating profile unlikely, which limits the ability of peripheral cytokines to provide insight into underlying pathophysiology in ME/CFS

Similarly, a previous preclinical study of VE supplementation did not significantly alter plasma levels of the pro-fibrotic cytokine TGF-1 or the adipocytokine leptin compared to the cholesterol-fed control group

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Chimploy K, Diaz GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, Dashwood RH (2009) E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin