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3h), demonstrating that it is, at least to some degree, under the control of the mTOR pathway

It is primarily researched for its interaction with nicotinamide N-methyltransferase (NNMT), an enzyme linked to energy balance and adipose tissue function

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Moreover, because MERCs formation serves as an important platform for MITOL-mediated ubiquitination of HMOX2, the effect of MERCs formation on mitochondrial iron homeostasis was assessed by measuring mitochondrial iron levels in PDZD8 KO and VAPB KO cells (Extended Data Fig