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Thus, in order to apprehend the structural basis of interoception, one must take into account three brain levels: the cerebral cortex, limbic system and brainstem, and also consider the tight links between the nervous and immune systems, connected through slow blood circulation and fast neuronal activity

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The intraperitoneal LD50 ranges from 134 to 240 mg/kg in rats and mice 60

To improve selectivity, some research teams introduce steric hindrance or modify the disulfide bond structure

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