fsp1 is a glutathione-independent ferroptosis suppressor GPX4-independent defense pathways. Cells suppress lipid Unleashing Ferroptosis in Human Cancers:

Unleashing Ferroptosis in Human Cancers: Targeting Ferroptosis Suppressor Protein 1 for Overcoming Therapy Resistance PPARa FSP1 axis modulates lipid peroxidation induced neuronal ferroptosis to promote functional recovery in mouse model of traumatic spinal cord injury Cellular and Molecular Life Sciences Springer Nature Link Molecular mechanisms of FSP1 regulated ferroptosis and therapeutic implications in various cancers Cellular & Molecular Biology Letters Springer Nature Link The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP 1 cells Molecular Medicine Springer Nature Link The suppression of FSP1 expression via NRF2 promotes ferroptosis induced by reactive oxygen species in vascular smooth muscle cells ScienceDirect

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