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Since high levels of adenosyl homocysteine are associated with dysfunctions in the methylation cycle and an accumulation of homocysteine, a phenomenon that increases oxidative stress and neuronal damage 38 , a reduction of these levels could lead to improved cell survival

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While these provide valuable mechanistic insights, additional in vivo studies are required to confirm the effects of FM19G11-loaded NPs on epSPC energy metabolism and, crucially, to demonstrate their capacity to promote neurogenesis

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