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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

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Baothman, O

(16) Diving deeper, the team sought to unravel the effects of this compound on the contractile dynamics of gastric smooth muscles when exposed to acetylcholine and electrical field stimulation