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The design of the screen is essential since your screen should be selective enough to eliminate non-useful variants, but not so stringent as to eliminate all variants

For example, bortezomib, a first-generation proteasome inhibitor that suppresses NF-B signalling and is approved for haematological malignancies, is associated with dose-limiting peripheral neuropathy, for which no approved prophylactic or therapeutic interventions currently exist [51, 52]

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GSH levels in blood and lung tissue in animals of different ages 6 hr after EtOH administration are reported in Table 6

The neuroprotective effects of EGCG, attributed to its antioxidant properties, have been observed in PD (Figure 4)