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Additional tests may include full blood count (looking for macrocytic anaemia), methylmalonic acid, and homocysteine levels

Phase 1a studies in healthy volunteers, published in Diabetes, Obesity and Metabolism in 2023, established the compound's single-dose and multiple-dose pharmacokinetics, confirming a half-life supportive of once-daily dosing, a favorable food-effect profile, and dose-proportional exposure across the tested range

The Food and Drug Administration's approval process is a formidable, multi-year gauntlet designed to verify the safety and efficacy of a substance as a medical treatment

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