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Important enzymes and cofactors are ATP synthase (complex V), cytochrome c oxidase (complex IV), NADH DH (complex I), pyruvate DH, and cofactors like NAD+/NADH and FAD

This vicious cycle of energetic failure not only drives disease progression but also reveals potential therapeutic targets

Following recruitment to sites of endothelial dysfunction, both monocyte-derived macrophages and resident intimal macrophages take up modified LDL and form foam cells that contribute to inflammatory processes within the plaque (132)

[194] From 1938, methamphetamine was marketed on a large scale in Germany as a nonprescription drug under the brand name Pervitin , produced by the Berlin-based Temmler pharmaceutical company

(2010) 5:e11519