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Further investigation into the testicular microenvironment using a co-culture system of senescent TM3 Leydig cells and GC-1 spg spermatogonia revealed that H2O2-induced senescent TM3 cells secreted increased levels of SASP factors, particularly IL-6 and TGF-

[DOI] [PubMed] [Google Scholar] 138.Kratz E.M., Piwowar A

A wealth of interventional data indicates that exercise improves multiple outcome measures in people with neurodegenerative disorders, which may partly relate to the activation of mitohormesis

CONCLUSION Based on the comprehensive review presented, EV-based therapeutics demonstrate transformative potential within AD research

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