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Patients report a significantly better tolerance compared to traditional options, making it suitable for a broader demographic, including those with pre-existing health concerns

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In addition to stating that estimands should be used, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines also emphasize the importance of considering intercurrent events when defining the scientific question of interest and underline key principles for handling missing data [3]

But in the case of B12 deficiency, homocysteine may rise beyond normal levels, causing irritation to the cardiovascular system and increasing inflammation