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An association between the presence of TDP-43 in the spinal cord and CTE cases with a progressive motor neuron disease, amyotrophic lateral sclerosis (ALS), is evidence that repetitive head trauma might be linked to impairments in the motor system

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Meyer et al., 2002b

[36] On 19 December 2014, the judge ruled that both girls were competent to stand trial

However, rare but severe adverse effects can occur upon long-term exposure or high doses, like osteonecrosis of the jaw or atypical femoral fractures (45)