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Upregulated PYCR1 expression has been demonstrated to activate STAT3 phosphorylation in lung cancer, which in turn leads to elevated PD-L1 expression and subsequent inhibition of T cell infiltration [113]

In early AD, fluorodeoxyglucose-PET showed a characteristic reduction of total glucose metabolism in the parietotemporal association cortices, posterior cingulate cortex and the precuneus (49)

Sulforaphane was found to attenuate pancreatic injury in a mouse model of acute pancreatitis by stimulating Nrf2-induced antioxidant enzymes (18)

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Li W, Mao L, Liu Y, Peng F, Sachs N, Wu W, Yiu SPT, Yan H, Schroeder A, Yu X, Jin K, Jiang S, Chen Z, Loth ML, Gomez L, Lubo I, Blank N, Samarah LZ, Basak A, Cho YW, Chen CY, Kim DM, Shalek AK, Solis Soto LM, Rabinowitz JD, Reilly MP, Qian X, Thaiss CA, Maegdefessel L, Wang L , Kadara H, Jiang S, Deng Y, Li M