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(ii) The GSH redox cycle, whose major role is to reduce cellular concentration of highly reactive (and potentially damaging) H 2 O 2 to homeostatic concentrations (110 nM) and to generate NADP + , used principally for the production of NADPH for the regulation of cellular metabolism and maintaining redox homeostasis [8]

*Correspondence: Yajun Lin, [email protected] Liu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, it is important to consider that many chimeric mouse ALS studies use whole-body irradiation as the regimen for bone marrow transplantation, which appears to cause disruptions in the BBB and thus could allow blood-derived monocytes to more freely enter the CNS and mature into microglia

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This makes it particularly valuable in advanced research where cellular repair, collagen signalling, inflammation response, and tissue regeneration overlap especially in skin and recovery-related models