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Kv1.3 channels are expressed on the surface of human T cells and are vital for activation by regulating membrane potential and calcium (Ca2 + ) signaling (180, 181)

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0.52.5 min, 95% B

consequently, reduced or temporally/spatially mismatched Treg-derived cytokines (TGF-, IL-10, and IL-35) can weaken mucosal tolerance and reparative programs, whereas context-dependent Treg overexpansion may impair antimicrobial immunity, resulting in dysregulated intestinal homeostasis 50,51

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