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The B12 component helps offset the fatigue that some people experience as their caloric intake naturally decreases

While there have been studies to show that people with MTHFR gene variants are more likely to have babies with neural tube defects, most of those studies were done in countries where there isnt routine folic acid fortification

70 In addition, a clinical trial in 20 individuals with tinnitus found supplementing with CoQ10 (300 mg per day of ubiquinone formulated with ethyl alcohol and lecithin) for 12 weeks led to reductions in scores on a tinnitus questionnaire in a subset of participants whose blood CoQ10 levels were low at the beginning of the trial

B12 shots fix deficiency-related fatigue and can restore normal appetite in people who were depleted, but they are not a reliable shortcut to meaningful weight loss in people with normal B12