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Indeed, IFN- concentration was significantly lower in the bone marrow of aged Mda5 -/- mice (Fig

Alibhai FJ, Reitz CJ, Peppler WT, Basu P, Sheppard P, Choleris E, Bakovic M, Martino TA (2018) Female Clock19/19 mice are protected from the development of age-dependent cardiomyopathy

By contrast, excessive suppression of macrophage activation impairs pathogen clearance and increases vulnerability to secondary infections, thereby disturbing immune homeostasis (195,196)