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In this case, reorganization of cytoskeleton can occur through direct oxidation and disruption of the cytoskeleton proteins leading to structural changes, or through inhibition of actin polymerization by interference with the signaling pathways involved in this process (Mittal et al., 2014)

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In contrast to the robust differences between the global metabolomes of lupus and control PBL at baseline, NAC treatment affected a narrow range of metabolites (Fig